Synthesis of a novel μ-acetate bridged dinuclear Cu(II) complex as model compound for the active site of tyrosinase: crystal structure, magnetic properties and catecholase activity

Reaction of the ligand N, N, N ′, N ′-bis[(2-hydroxybenzyl)( N-methylimidazolyl)]-2-ol-1,3-propendiamine (Hbhbmipo) with copper(II) perchlorate and sodium acetate in acetonitrile/ethanol leads to the assembly of a novel dinuclear copper(II) complex. The crystal structure, magnetic properties and its...

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Bibliographic Details
Published in:Inorganic chemistry communications 2001-12, Vol.4 (12), p.753-756
Main Authors: Gentschev, Pavel, Lüken, Matthias, Möller, Niclas, Rompel, Annette, Krebs, Bernt
Format: Article
Language:English
Subjects:
Catecholase activity
Copper(II) complex
Crystal structure
Model compound
Tyrosinase
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Summary:Reaction of the ligand N, N, N ′, N ′-bis[(2-hydroxybenzyl)( N-methylimidazolyl)]-2-ol-1,3-propendiamine (Hbhbmipo) with copper(II) perchlorate and sodium acetate in acetonitrile/ethanol leads to the assembly of a novel dinuclear copper(II) complex. The crystal structure, magnetic properties and its catecholase activity are reported. Both copper(II) ions are set in a distorted square pyramidal coordination sphere with a N 2O 3 donor set resulting in a Cu⋯Cu distance of 3.382(5) Å. To our knowledge this is the first example of a dinuclear Cu(II) complex with square pyramidal coordination geometry in which the N 2O 3 donor set contains N-imidazol and O-phenol. The complex represents a structural model for a tyrosine intermediate in the proposed mechanism during hydroxylation of monophenols.
ISSN:1387-7003
1879-0259
DOI:10.1016/S1387-7003(01)00317-3