Novel Ionophore for the Potentiometric Determination of Cetirizine Hydrochloride in Pharmaceutical Formulations and Human Urine

• Published in: International journal of electrochemical science 2009-03, Vol.4 (3), p.396-406
• Main Authors: Rizk, Nashwa M.H., Abbas, Samah S., EL-Sayed, Fathy A., Abo-Bakr, Ahmed
• Format: Article
• Language: English
• Subjects: carbon paste electrodes; Cetirizine; human urine; pharmaceutical formulation; potentiometry; sensors; β-cyclodextrin
• ISSN: 1452-3981; 1452-3981
• DOI: 10.1016/S1452-3981(23)15150-9

Cetirizine (CT) membrane sensors of conventional (CE) and carbon paste (CPE) have been prepared, based on β-cyclodextrin (βCD) as ionophore and potassium tetrakis[3,5-bis(trifluoro-methyl) phenyl]borate (KTFPB) as anionic membrane additive. The sensors exhibit a linear response with a mean calibration graph slopes of 60.2 and 57.4 mV per decade at 25 °C for conventional and carbon paste electrodes, respectively, with the concentration ranges 1x10-1-5x10-6 M for conventional and 1x10-1-7x10-6 M for carbon paste. The electrodes fully characterized in terms of composition, usable pH range, life span and response time. The electrodes showed a very good selectivity for CT with respect to some inorganic and organic cations and other related compounds. Use of the sensors for the assay of formulation of CT drug and in spiked human urine, show a mean average recovery of 100.04 % and a mean precision of ± 0.4. Significantly improved response time, stability, selectivity, accuracy, simple, and low cost are offered by potentiometric sensors compared with other standard methods.