Determination of Ketoconazole on a Gold Disk Microelectrode

The oxidation of ketoconazole (an antifungal agent and strong CYP3A inhibitor) was investigated using a gold disk microelectrode of 25 μm in diameter. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were applied as electrochemical techniques. The stability of the gold microelectrode...

Full description

Saved in:
Bibliographic Details
Published in:International journal of electrochemical science 2016, Vol.11 (2), p.1676-1690
Main Authors: Gladysz, O., Łoś, P., Karolewicz, B., Górniak, A.
Format: Article
Language:English
Subjects:
diffusion coefficients
gold disk microelectrode
ketoconazole oxidation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The oxidation of ketoconazole (an antifungal agent and strong CYP3A inhibitor) was investigated using a gold disk microelectrode of 25 μm in diameter. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were applied as electrochemical techniques. The stability of the gold microelectrode was tested by CV and A.C. impedance methods. Also, diffusion coefficients were determined. The influence of pH on the electroanalytical response was studied. It was found that voltamperometric responses are selective for ketoconazole and the linear equations of the peak current versus ketoconazole concentration were obtained for pharmaceutical preparations: tablets, shampoo and cream. The advantages of the use of microelectrodes include the possibility of miniaturization, very low currents in the range of 10-9A and simplicity of sample preparation which may help to develop an analytical method. To our knowledge, the data presented here represent the first systematic studies of ketoconazole oxidation using microelectrodes.
ISSN:1452-3981
1452-3981
DOI:10.1016/S1452-3981(23)15951-7