Amino acids are still as exciting as ever

Glutamate is probably the most important excitatory transmitter in the vertebrate central nervous system. Its multiple functional roles in the brain and spinal cord make therapeutic manipulation of these systems fraught with difficulties. There has, however, been recent progress in pharmacological m...

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Bibliographic Details
Published in:Current Opinion in Pharmacology 2001-02, Vol.1 (1), p.57-61
Main Authors: Carpenter, Kate J, Dickenson, Anthony H
Format: Article
Language:English
Subjects:
AMPA
Animals
Calcium
Dipeptides - physiology
Glutamate
Humans
Ionotropic
Kainate
Metabotropic
NAAG
Neurotransmitter Agents - physiology
NMDA
Nociception
Receptors, Metabotropic Glutamate - drug effects
Receptors, Metabotropic Glutamate - physiology
Receptors, N-Methyl-D-Aspartate - drug effects
Receptors, N-Methyl-D-Aspartate - physiology
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Summary:Glutamate is probably the most important excitatory transmitter in the vertebrate central nervous system. Its multiple functional roles in the brain and spinal cord make therapeutic manipulation of these systems fraught with difficulties. There has, however, been recent progress in pharmacological manipulations of NMDA receptor subtypes and non-NMDA receptors, and understanding of the roles of NAAG, that promise rapid advances in pain control.
ISSN:1471-4892
1471-4973
DOI:10.1016/S1471-4892(01)00009-1