Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol

Uric acid has been hypothesized as being one of the more important antioxidants in limiting the accumulation of glycosylated endproducts in birds. Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effec...

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Bibliographic Details
Published in:Comparative biochemistry and physiology. Toxicology & pharmacology 2001-06, Vol.129 (2), p.93-104
Main Authors: Klandorf, H, Rathore, D.S, Iqbal, M, Shi, X, Van Dyke, K
Format: Article
Language:English
Subjects:
Aging - metabolism
Allopurinol
Allopurinol - administration & dosage
Allopurinol - pharmacology
Animals
Antimetabolites - pharmacology
Arginine - analogs & derivatives
Arginine - pharmacology
Blood Glucose - analysis
Blood Glucose - drug effects
Body Weight - drug effects
Broiler chickens
Chickens - blood
Chickens - metabolism
Cross-Linking Reagents - pharmacology
Diet
Glycation End Products, Advanced - metabolism
Glycosylation
Hemin - administration & dosage
Hemin - pharmacology
Luminescent Measurements
Lysine - analogs & derivatives
Lysine - pharmacology
Muscle, Skeletal - drug effects
Oxidative Stress
Skin - metabolism
Skin pentosidine
Uric acid
Uric Acid - blood
Uric Acid - metabolism
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Summary:Uric acid has been hypothesized as being one of the more important antioxidants in limiting the accumulation of glycosylated endproducts in birds. Study 1 was designed to quantitatively manipulate the plasma concentrations of uric acid using hemin and allopurinol while study 2 determined their effects on skin pentosidine, the shear force value of Pectoralis major muscle, plasma glucose, body weight and chemiluminescence monitored oxidative stress in broiler chickens. Hemin was hypothesized to raise uric acid concentrations thereby lowering oxidative stress whereas allopurinol was hypothesized to lower uric acid concentrations and raise measures of oxidative stress. In study 1 feeding allopurinol (10 mg/kg body weight) to 8-week-old broiler chicks ( n=50) for 10 days decreased plasma uric acid by 57%. However, hemin (10 mg/kg body weight) increased uric acid concentrations 20%. In study 2, 12-week-old broiler chicks ( n=90) were randomly assigned to either an ad libitum (AL) diet or a diet restricted (DR) group. Each group was further divided into three treatments (control, allopurinol or hemin fed). Unexpectedly, hemin did not significantly effect uric acid concentrations but increased ( P
ISSN:1532-0456
1878-1659
DOI:10.1016/S1532-0456(01)00186-7