Effects of Bacillus thuringiensis toxin on hepatic lipid peroxidation and free-radical scavengers in rats given alpha-tocopherol or acetylsalicylate

The effect of Dipel (D), a Bacillus thuringiensis-based bioinsecticide, on hepatic antioxidant enzyme activities and lipid peroxidation in rat liver was investigated. Administration of D in a dose of 1 mg/100 g body mass for 4 successive days increased the activities of glutathione peroxidase (GPx),...

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Published in:Comparative biochemistry and physiology. Toxicology & pharmacology 2003-08, Vol.135 (4), p.405-414
Main Authors: Shaban, Nadia Z., Helmy, Madiha H., El-Kersh, Mohamed A.R., Mahmoud, Bothaina F.
Format: Article
Language:English
Subjects:
Acetylsalicylic acid
alpha-Tocopherol - pharmacology
Animals
Antioxidant enzyme
Antioxidants - pharmacology
Aspirin - analogs & derivatives
Aspirin - pharmacology
Bacillus thuringiensis
Bacillus thuringiensis - chemistry
Bacterial Proteins - toxicity
Bacterial Toxins
Dipel
Endotoxins - toxicity
Free Radical Scavengers - pharmacology
Glutathione - analysis
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Hemolysin Proteins
Insecticide
Lipid peroxidation
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Male
Malondialdehyde - analysis
Malondialdehyde - metabolism
Oxidative stress
Rats
Rats, Wistar
Selenium - metabolism
Superoxide Dismutase - metabolism
α-Tocopherol
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Summary:The effect of Dipel (D), a Bacillus thuringiensis-based bioinsecticide, on hepatic antioxidant enzyme activities and lipid peroxidation in rat liver was investigated. Administration of D in a dose of 1 mg/100 g body mass for 4 successive days increased the activities of glutathione peroxidase (GPx), glutathione reductase (GR) and the level of malondialdehyde (MDA) in rat hepatocytes. The activity of superoxide dismutase (SOD) and glutathione (GSH) level were decreased. Administration of D in rats pretreated with α-tocopherol (αT) or acetylsalicylic acid (ASA) decreased the activities of GPx, GR and MDA levels, while the GSH level was increased compared with rats treated with D alone. The SOD activity was increased in rats pretreated with αT before D, but decreased on pretreatment with ASA, compared with rats treated with D alone. The results indicated that D induced oxidative stress in rat liver that has been protected by prior administration of αT or ASA.
ISSN:1532-0456
1878-1659
DOI:10.1016/S1532-0456(03)00142-X