192 ABPAs in Pseudomonas aeruginosa colonized CF patients

Objectives Allergic Bronchopulmonary Aspergillosis syndrome (ABPAs) occurs in 10 to 15% of the CF patients. We intend to study facilitators and consequences of ABPAs in P. aeruginosa (Ps) colonized CF patients. Methods Sixty four ABPAs and Ps colonized patients matched for age and gender were compar...

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Bibliographic Details
Published in:Journal of cystic fibrosis 2015-06, Vol.14, p.S107-S107
Main Authors: De Baets, F, De Keyzer, L, Schelstraete, P, Van Daele, S, Wanyama, S
Format: Article
Language:English
Subjects:
Pulmonary/Respiratory
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Summary:Objectives Allergic Bronchopulmonary Aspergillosis syndrome (ABPAs) occurs in 10 to 15% of the CF patients. We intend to study facilitators and consequences of ABPAs in P. aeruginosa (Ps) colonized CF patients. Methods Sixty four ABPAs and Ps colonized patients matched for age and gender were compared to 128 controls. FEV1, FVC, infectious exacerbations and BMI were studied 10 years before until 10 years after the index year. Results On the index year no differences were found for BMI, FVC and FEV1. Patients with ABPAs have a higher prevalence of CFRD and significantly more were on treatment with inhaled corticosteroids, RhDnase, azithromycin and inhaled tobramycin. Cumulative values (FEV1, FVC, days of IV antibiotics) over the period before the index year were similar, over the 10 years period after the index year significantly lower values for FEV1 (p
ISSN:1569-1993
1873-5010
DOI:10.1016/S1569-1993(15)30369-6