Reaction mechanism and regulation of cystathionine β-synthase

In mammals, cystathionine β-synthase catalyzes the first step in the transsulfuration pathway which provides an avenue for the conversion of the essential amino acid, methionine, to cysteine. Cystathionine β-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine...

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Bibliographic Details
Published in:BBA - Proteins and Proteomics 2003-04, Vol.1647 (1), p.30-35
Main Authors: Banerjee, Ruma, Evande, Ruby, Kabil, Ömer, Ojha, Sunil, Taoka, Shin
Format: Article
Language:English
Subjects:
Allosteric Regulation
Cystathionine beta-Synthase - chemistry
Cystathionine beta-Synthase - metabolism
Cystathionine β-synthase
Heme
Heme - chemistry
Homocysteine
Humans
Kinetics
Oxidation-Reduction
Pyridoxal phosphate
Redox
S-Adenosylmethionine - pharmacology
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Summary:In mammals, cystathionine β-synthase catalyzes the first step in the transsulfuration pathway which provides an avenue for the conversion of the essential amino acid, methionine, to cysteine. Cystathionine β-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine and is unique in also having a heme cofactor. In this review, recent advances in our understanding of the kinetic mechanism of the yeast and human enzymes as well as pathogenic mutants of the human enzyme and insights into the role of heme in redox sensing are discussed from the perspective of the crystal structure of the catalytic core of the human enzyme.
ISSN:1570-9639
0006-3002
1878-1454
DOI:10.1016/S1570-9639(03)00044-X