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Surgery of female genital tract tumour lung metastases

Abstract Introduction Lung metastases originating from tumors of the female genital tract are rare. Due to this rarity and their variable histology, it has been difficult to compare different patient series. Material and methods A retrospective study of patients who underwent resection of lung metas...

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Published in:Archivos de bronconeumología (English ed.) 2011, Vol.47 (3), p.134-137
Main Authors: González Casaurrán, Guillermo, Simón Adiego, Carlos, Peñalver Pascual, Rafael, Moreno Mata, Nicolás, Lozano Barriuso, Miguel Ángel, González Aragoneses, Federico
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Language:English
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Summary:Abstract Introduction Lung metastases originating from tumors of the female genital tract are rare. Due to this rarity and their variable histology, it has been difficult to compare different patient series. Material and methods A retrospective study of patients who underwent resection of lung metastases of female genital tract tumors (uterine, fallopian and cervical cancer) during the period from 01/01/1989 to 12/31/2006. Epidemiological, diagnostic and treatment data were collected. Non-parametric tests and the survival analysis were performed using the Kaplan-Meier curves and the log-rank test. Results During the study period, 27 underwent resection. Mean disease-free interval (DFI) from initial diagnosis to the diagnosis of metastasis was 58 months (1–195 months). Mean survival from the diagnosis of metastasis was 94 months. The overall 5-year survival after diagnosis of metastasis was 84.1%. A second surgery for metastasis was performed on 5 patients (18.5%). Survival after second surgery of metastases was 80.5 months. Five-year survivals from diagnosis of metastasis were: endometrial carcinoma 100%; cervical cancer 62.5%; uterine sarcoma 60%. Adjuvant hormone therapy was prescribed in15 out of 16 patients with endometrial carcinoma. There was a statistically significant difference in survival depending on the histological type and disease free interval. Conclusion Surgical treatment of lung metastases originating from female genital tract tumors (mainly endometrial carcinoma) is associated with a high long-term survival.
ISSN:1579-2129
1579-2129
DOI:10.1016/S1579-2129(11)70032-5