Follicular populations, recruitment and atresia in the ovaries of different strains of mice

SUMMARY Follicular atresia is a key event in the selection of the ovulatory follicles and occurs during all developmental stages. The aims of the study were to evaluate the follicular population as well as the rates of follicular recruitment and atresia in different strains of mice. Ovaries were obt...

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Published in:Reproductive biology 2012-03, Vol.12 (1), p.41-55
Main Authors: Campos-Junior, Paulo Henrique Almeida, Assuncao, Carolina Marinho, Carvalho, Bruno Campos, Batista, Ribrio Ivan Tavares Pereira, Garcia, Raúl Marcel González, Viana, Joao Henrique Moreira
Format: Article
Language:English
Subjects:
apoptosis
caspase-3
folliculogenesis
heterosis
Obstetrics and Gynecology
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Summary:SUMMARY Follicular atresia is a key event in the selection of the ovulatory follicles and occurs during all developmental stages. The aims of the study were to evaluate the follicular population as well as the rates of follicular recruitment and atresia in different strains of mice. Ovaries were obtained from four strains of mice: G1/Swiss, G2/F1 Swiss×C57BL/6, G3/inbred strain C57BL/6, and G4/F1 C57BL/6×Swiss. All mice used in the study were 60 days old. Ovaries collected from the mice were fixed and processed for histological analysis. The G2 ovaries were also used to examine immunolocalization of active caspase-3. The pimordial follicle population was smaller in G3 mice than in G1, G2 and G4 groups (7 565±1 845 vs. 17 180±3 159, 14 785±3 319 and 13 325±2 685, respectively; p
ISSN:1642-431X
DOI:10.1016/S1642-431X(12)60076-X