Short communication - Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus

Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. The in vitro low Mg2+ seizure model is used to emulate difficult-to-treat status epilepticus. Using this model on cultured hippocampal slices, we examined...

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Bibliographic Details
Published in:Pharmacological reports 2011-05, Vol.63 (3), p.840-844
Main Authors: Isaeva, Elena, Lushnikova, Irina, Savrasova, Alina, Skibo, Galina, Holmes, Gregory L., Isaev, Dmytro
Format: Article
Language:English
Subjects:
hippocampus
neuraminidase
seizures
surface charge
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Summary:Negatively charged sialic acid residues located close to pores of voltage-gated sodium channels substantially influence their gating properties. The in vitro low Mg2+ seizure model is used to emulate difficult-to-treat status epilepticus. Using this model on cultured hippocampal slices, we examined the effectiveness of desialylation in reducing persistent seizure-like activity. We show that desialylation in cultured hippocampal slices effectively suppresses seizure-like activity induced by low Mg2+. These findings suggest that targeting negatively charged sialic acids may be an effective strategy to treat status epilepticus.
ISSN:1734-1140
2299-5684
DOI:10.1016/S1734-1140(11)70597-7