H009 Hyperoxia produces a deactivation of metaboreflex in chronic heart failure

Introduction In healthy subject hyperoxia enhances metaborefl ex sensitivity during static exercise. However the infl uence of chronic heart failure on metaborefl ex sensibility remains a matter of controversies. Moreover the effect of hyperoxia on this refl ex in CHF patients is unknown. This is of...

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Bibliographic Details
Published in:Archives of cardiovascular diseases 2009, Vol.102, p.S74-S74
Main Authors: Despas, F, Labrunee, M, Franchitto, N, Galinier, M, Senard, J.-M, Pathak, A
Format: Article
Language:English
Subjects:
Cardiovascular
Internal Medicine
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Summary:Introduction In healthy subject hyperoxia enhances metaborefl ex sensitivity during static exercise. However the infl uence of chronic heart failure on metaborefl ex sensibility remains a matter of controversies. Moreover the effect of hyperoxia on this refl ex in CHF patients is unknown. This is of importance since these patients regularly receive chronic administration of nasal oxygen during hospital admission. Methods The effects of breathing 21 % (normoxia) and 100 % oxygen (hyperoxia) at rest and during isometric handgrip at 30 % of maximal voluntary contraction on MSNA, heart rate (HR), blood pressure (systolic, diastolic, mean and pulse pressure) and O2 saturation (SaO2) were determined in 14 patients with heart failure. The isometric handgrips were followed by 3 min of postexercise circulation arrest (PE-CA) to allow metaborefl ex activation in the absence of other refl ex mechanisms. Results In normoxia, hangrip and PE-CA induced an expected increase in MSNA and hemodynamic parameters (BP, HR; all p
ISSN:1875-2136
1875-2128
DOI:10.1016/S1875-2136(09)72308-3