Effects of Cisapride on QT Interval in Children

This prospective study evaluated the effects of cisapride on corrected QT interval (QTc) in infants and children. From October 2000 to March 2003 two electrocardiograms (ECG) were obtained for 175 children (ranging in age from 1.5 months to 16.8 years), before and after 15 days of treatment with cis...

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Bibliographic Details
Published in:Revista española de cardiología (English ed.) 2004, Vol.57 (1), p.89-93
Main Authors: Tamariz-Martel Moreno, Amalia, Baño Rodrigo, Antonio, Sánchez Bayle, Marciano, Montero Luis, Cristina, Acuña Quirós, María D., Cano Fernández, Julia
Format: Article
Language:English
Subjects:
Arrhythmia
Arritmia
Children
Cisaprida
Cisapride
Intervalo QT
Niños
QT interval
Tachycardia
Taquicardia
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Summary:This prospective study evaluated the effects of cisapride on corrected QT interval (QTc) in infants and children. From October 2000 to March 2003 two electrocardiograms (ECG) were obtained for 175 children (ranging in age from 1.5 months to 16.8 years), before and after 15 days of treatment with cisapride (0.2 mg/kg/dose, 3-4 times/day). A single posttreatment ECG was also obtained for 24 patients (ranging in age from 1.5 month to 15.8 years). No statistically significant differences were found between the mean QTc interval before (0.390 [0.018 s]) and after treatment (0.391 [0.018 s]). In patients for whom only a posttreatment ECG recording was performed, mean QTc interval was 0.399 (0.018 s). The QTc interval was never longer than 0.450 s in any of the children. In our experience the use of cisapride at therapeutic doses in infants and children who have no associated risk factors does not significantly prolong QTc interval. Se valoró de forma prospectiva el efecto en el intervalo QT corregido (QTc) del tratamiento con cisaprida en niños. Desde octubre de 2000 a marzo de 2003, se realizó un electrocardiograma (ECG) basal y otro a los 15 días de tratamiento con cisaprida (0,2 mg/kg/dosis, 3-4 veces/día) a 175 niños (edad entre 1,5 meses y 16,8 años). Además, se realizó un único ECG postratamiento a 24 niños (edad entre 1,5 meses y 15,8 años). No se encontraron diferencias estadísticamente significativas entre el intervalo QTc medio basal (0,390 plusmn; 0,018 s) y postratamiento (0,391 plusmn; 0,018 s). En los enfermos con un único ECG postratamiento, el intervalo QTc medio fue de 0,399 plusmn; 0,018 s. En ningún caso el intervalo QTc superó los 0,450 s. Según nuestra experiencia, la utilización de cisaprida en dosis terapéuticas en niños sin factores de riesgo asociados no prolonga significativamente el intervalo QTc.
ISSN:1885-5857
1885-5857
DOI:10.1016/S1885-5857(06)60093-5