ALL-276: Complex Karyotype with ≥3 Cytogenetic Alterations is a New Marker of Worse Prognosis in Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)

• Published in: Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2020-09, Vol.20, p.S167-S168
• Main Authors: Genesca, Eulalia, Morgades, Mireia, Gonzalez-Gil, Celia, Fuster-Tormo, Francisco, Haferlach, Claudia, Meggendorfer, Manja, Montesinos, Pau, Barba, Pere, Gil, Cristina, Coll, Rosa, Moreno, Maria Jose, Martinez-Carballeira, Daniel, Garcia-Cadenas, Irene, Vives, Susana, Ribera, Jordi, Gonzalez-Campos, Jose, Diaz-Beya, Marina, Mercadal, Santiago, Artola, Teresa, Cladera, Antonia, Tormo, Mar, Bermudez, Arancha, Vall-llovera, Ferran, Martinez-Sanchez, Pilar, Amigo, Mari-Luz, Monsalvo, Silvia, Novo, Andres, Cervera, Marta, Garcia-Griñon, Antonio, Ciudad, Juana, Cervera, Jose, Hernandez-Rivas, Jesus-Maria, Granada, Isabel, Haferlach, Torsten, Orfao, Alberto, Sole, Francesc, Ribera, Josep Maria
• Format: Article
• Language: English
• Subjects: acute lymphoblastic leukemia; adult T-ALL; karyotype1 NGS; next-generation sequencing; prognosis; treatment
• ISSN: 2152-2650; 2152-2669
• DOI: 10.1016/S2152-2650(20)30690-X

No standardized and widely accepted cytogenetic classification with prognostic impact for adult T-ALL has been proposed to date. Patients with abnormal karyotypes (65/139, 47%) were classified according to the number of chromosomal alterations (Chun K. et al., 2009). 216 adults T-ALL patients/NCT00853008-NCT01540812/PETHEMA cooperative group. Prognostic impact of karyotype on event-free survival (EFS), overall survival (OS), and cumulative incidence of relapse (CIR) were assessed. Additionally, next-generation sequencing (NGS) experiments were done. Greater than three cytogenetic abnormalities were associated with lower rates of both complete remission (CR, 77% vs. 94%; p=0.032) and minimal residual disease (MRD) level