One hour effects of salbutamol and formoterol on blood pressure, heart rate and oxygen saturation in asthmatics

Abstract Aim To analyse systolic (SBP) and diastolic blood pressure (DBP), partial oxygen saturation (SpO2 ) and heart rate (HR) disorders for an hour after short and long acting ß2 -agonists. Material and methods Twenty-four severe persistent asthma Pulmonology outpatients at Hospital Universitario...

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Bibliographic Details
Published in:Revista portuguesa de pneumologia (English ed.) 2008-05, Vol.14 (3), p.353-361
Main Authors: Capuchinho-Júnior, Geraldo Andrade, Dias, Ricardo Marques, da Silva de Carvalho, Sônia Regina
Format: Article
Language:English
Subjects:
Asma
Asthma
blood pressure
bronchodilator agents/adverse effects
broncodilatadores/efeitos adversos
frequência cardíaca
heart rate
Internal Medicine
oxygen saturation
pressão arterial sistémica
Pulmonary/Respiratory
saturação de oxigénio
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Summary:Abstract Aim To analyse systolic (SBP) and diastolic blood pressure (DBP), partial oxygen saturation (SpO2 ) and heart rate (HR) disorders for an hour after short and long acting ß2 -agonists. Material and methods Twenty-four severe persistent asthma Pulmonology outpatients at Hospital Universitario Gaffree e Guinle were selected. SBP, DBP, SpO2 and HR values were determined before and after 400 μg of salbutamol and 12 μg of formoterol, on different days, with a minimum interval of 24 hours. Results All patients showed ventilatory obstruction, as seen by a reduced FEV1/FVC ratio. There was no statistical SBP/DBP/HR difference after bronchodilator agents, but SpO2 increased with salbutamol. Conclusion A standard dose of salbutamol and formoterol does not cause haemodynamic disorder.
ISSN:2173-5115
2173-5115
DOI:10.1016/S2173-5115(08)70266-5