Evaluation of Trapa bispinosa Roxb. starch as pharmaceutical binder in solid dosage form

To evaluate binding efficiency of Trapa bispinosa Roxb. starch (TBS) in diclofenac sodium tablets. Diclofenac sodium tablets were prepared using wet granulation method. The starch paste in different concentrations (5%-15% w/w) was evaluated for optimized binder concentration. Preformulation study of...

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Bibliographic Details
Published in:Asian Pacific journal of tropical biomedicine 2011, Vol.1 (1), p.S86-S89
Main Authors: Singh, Akhilesh V, Singh, Anudwipa, Nath, Lila K, Pani, Nihar R
Format: Article
Language:English
Subjects:
Binder
Diclofenac sodium
FTIR
IST
Trapa bispinosa starch
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Summary:To evaluate binding efficiency of Trapa bispinosa Roxb. starch (TBS) in diclofenac sodium tablets. Diclofenac sodium tablets were prepared using wet granulation method. The starch paste in different concentrations (5%-15% w/w) was evaluated for optimized binder concentration. Preformulation study of the drug with TBS and different excipients were also analyzed using fourier transform infrared spectroscopy (FTIR) and isothermal stress testing (IST). Preformulation study of the drug, water chestnut starch and different excipients showed no interaction or, drug degradation in FTIR and IST, respectively. The tablets were evaluated for hardness, friability, drug content, disintegration and dissolution studies, and all the parameters were found within the official specifications. The results reveal that this starch has potential to be used as binder at industrial scale in pharmaceutical solid dosage form development.
ISSN:2221-1691
2588-9222
DOI:10.1016/S2221-1691(11)60131-7