A nanogel of on-site tunable pH-response for efficient anticancer drug delivery

A smart, soft and small nanoparticulate drug carrier that can efficiently transport therapeutics into tumor cells to control the intracellular drug concentration will enable major advancements in cancer therapy. To facilitate a remote modulation of the intracellular pH-regulated drug release, we hav...

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Bibliographic Details
Published in:Acta biomaterialia 2013-01, Vol.9 (1), p.4546-4557
Main Authors: Zhou, Ting, Xiao, Chuanfu, Fan, Jiao, Chen, Shoumin, Shen, Jing, Wu, Weitai, Zhou, Shuiqin
Format: Article
Language:English
Subjects:
acidity
Adsorption
antineoplastic agents
Antineoplastic Agents - administration & dosage
Chitosan
cooling
Drug Carriers
Drug delivery
Gels
heat
Hydrogen-Ion Concentration
melanoma
Microscopy, Electron, Transmission
Nanostructures
pH-responsive nanogels
Poly(ethylene glycol)
polyethylene glycol
Polyethylene Glycols
Quantum Dots
Remotely modulate
Serum Albumin - chemistry
toxicity
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Summary:A smart, soft and small nanoparticulate drug carrier that can efficiently transport therapeutics into tumor cells to control the intracellular drug concentration will enable major advancements in cancer therapy. To facilitate a remote modulation of the intracellular pH-regulated drug release, we have designed a new class of pH-responsive chitosan-based nanogels (
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2012.08.017