The role of positron emission tomography/computed tomography imaging with radiolabeled choline analogs in prostate cancer

Abstract Introduction Prostate cancer is the most frequent solid malignant tumor in Western countries. Positron emission tomography/X-ray computed tomography imaging with radiolabeled choline analogs is a useful tool for restaging prostate cancer in patients with rising prostate-specific antigen aft...

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Bibliographic Details
Published in:Actas urológicas españolas (English ed.) 2014-11, Vol.38 (9), p.613-621
Main Authors: Navarro-Pelayo Láinez, M.M, Rodríguez-Fernández, A, Gómez-Río, M, Vázquez-Alonso, F, Cózar-Olmo, J.M, Llamas-Elvira, J.M
Format: Article
Language:English
Subjects:
Biochemical relapse
Choline
Cinética PSA
Colina
Cáncer de próstata
Estadificación
PET/CT
PET/TC
Prostate cancer
PSA kinetics
Recurrencia bioquímica
Staging
Urology
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Summary:Abstract Introduction Prostate cancer is the most frequent solid malignant tumor in Western countries. Positron emission tomography/X-ray computed tomography imaging with radiolabeled choline analogs is a useful tool for restaging prostate cancer in patients with rising prostate-specific antigen after radical treatment (in whom conventional imaging techniques have important limitations) as well as in the initial assessment of a selected group of prostate cancer patients. For this reason a literature review is necessary in order to evaluate the usefulness of this imaging test for the diagnosis and treatment of prostate cancer. Evidence acquisition A MEDLINE (PubMed way) literature search was performed using the search parameters: «Prostate cancer» and «Choline-PET/CT». Other search terms were «Biochemical failure» and/or «Staging» and/or «PSA kinetics». English and Spanish papers were selected; original articles, reviews, systematic reviews and clinical guidelines were included. Conclusions According to available data, radiolabeled choline analogs plays an important role in the management of prostate cancer, especially in biochemical relapse because technique accuracy is properly correlated with prostate-specific antigen values and kinetics. Although is an emerging diagnostic technique useful in treatment planning of prostate cancer, final recommendations have not been submitted.
ISSN:2173-5786
2173-5786
DOI:10.1016/j.acuroe.2014.04.004