Physical and chemical profiles of nanoparticles for lymphatic targeting

Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively expl...

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Bibliographic Details
Published in:Advanced drug delivery reviews 2019-11, Vol.151-152, p.72-93
Main Authors: Ke, Xiyu, Howard, Gregory P., Tang, Haoyu, Cheng, Bei, Saung, May Tun, Santos, José L., Mao, Hai-Quan
Format: Article
Language:English
Subjects:
Immune cells
Immunotherapy
Lymph node
Nanoparticles
Physicochemical properties
Vaccine
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Summary:Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy. [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2019.09.005