Glomeruloid Hemangioma and POEMS Syndrome

• Published in: Actas dermo-sifiliográficas (English ed.) 2017-03, Vol.108 (2), p.e15-e19
• Main Authors: Hernández Aragüés, I, Pulido Pérez, A, Ciudad Blanco, C, Parra Blanco, V, Suárez Fernández, R
• Format: Article
• Language: English
• Subjects: Aged, 80 and over; Dermatology; Dermoscopy; Endocrinopathy; Endocrinopatía; Female; Glomeruloid hemangioma; Hemangioma - etiology; Hemangioma - pathology; Hemangioma glomeruloide; Humans; Internal Medicine; M proteína; M-protein; Middle Aged; Multiple Myeloma - complications; Multiple Myeloma - diagnosis; Organomegalia; Organomegaly; Paraneoplastic syndrome; Paraneoplastic Syndromes - etiology; Paraneoplastic Syndromes - pathology; Plasmacytoma - complications; Plasmacytoma - diagnostic imaging; POEMS Syndrome - etiology; POEMS Syndrome - pathology; Polyneuropathy; Positron Emission Tomography Computed Tomography; Skin abnormalities; Skin abnormalities syndrome; Skin Neoplasms - etiology; Skin Neoplasms - pathology; Síndrome de Polineuropatía; Síndrome paraneoplásico
• ISSN: 1578-2190; 2173-5778; 1578-2190
• DOI: 10.1016/j.adengl.2016.12.006

Abstract POEMS syndrome is a paraneoplastic manifestation associated with hematopoietic disorders such as multiple myeloma and Castleman disease. POEMS is an acronym for the main clinical features of the syndrome, namely, Polyneuropathy, Organomegaly, Endocrinopathy, M protein, and Skin abnormalities. Glomeruloid hemangiomas are considered to be a specific clinical marker of POEMS syndrome. However, while they are not pathognomonic, their presence should raise suspicion of this syndrome or alert clinicians to its possible future development, as these lesions can appear years before the onset of the syndrome. We report the cases of 2 women with plasma cell dyscrasias and sudden onset of lesions with a vascular appearance and histologic findings consistent with glomeruloid hemangioma. Recognition of this vascular tumor is important for the early diagnosis of POEMS syndrome.