Perineural Invasion in Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, t...

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Bibliographic Details
Published in:Actas dermo-sifiliográficas (English ed.) 2019-07, Vol.110 (6), p.426-433
Main Authors: Pérez García, M.P., Mateu Puchades, A., Sanmartín Jiménez, O.
Format: Article
Language:English
Subjects:
Alto riesgo
Carcinoma epidermoide
High risk
Infiltración perineural
Perineural infiltration
Radioterapia
Radiotherapy
Squamous cell carcinoma
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Summary:Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, that is, the spread of tumor cells into the space surrounding a nerve, is usually an incidental finding. In the presence of symptoms or radiographic evidence of perineural spread, the diagnosis is clinical perineural invasion, which is associated with an increased risk of local recurrence and mortality. En ocasiones el carcinoma epidermoide cutáneo se caracteriza por tener un mayor riesgo de desarrollar recurrencia locorregional y ocasionalmente metástasis a distancia. Existen diversos factores clínico-patológicos de reconocido valor pronóstico, entre ellos la presencia de infiltración perineural. Esta consiste en la diseminación de células tumorales a través de los nervios, siendo en la mayoría de los casos un hallazgo incidental. Cuando aparecen síntomas y/o evidencia radiológica de la extensión de la infiltración perineural, se clasifica como infiltración perineural clínica y se asocia a un mayor riesgo de recurrencia local y de mortalidad.
ISSN:1578-2190
1578-2190
2173-5778
DOI:10.1016/j.adengl.2019.05.007