Cutibacterium acnes tetracycline resistance profile in patients with acne vulgaris, in a Colombian dermatologic center

• Published in: Actas dermo-sifiliográficas (English ed.) 2021-11, Vol.112 (10), p.873-880
• Main Authors: Castellanos Lorduy, H.J., Pérez Cely, H.C., Casadiego Rincón, E.J., Henao Riveros, S.C., Colorado, C.L.
• Format: Article
• Language: English
• Subjects: Acne treatment; Cutibacterium acnes; Resistance to antibiotics; Resistance to cyclines; Resistencia a las ciclinas; Resistencia a los antibióticos; Tratamiento del acné
• ISSN: 1578-2190; 1578-2190; 2173-5778
• DOI: 10.1016/j.adengl.2021.09.003

Acne is a chronic inflammatory disease, in which different events intervene in its pathogenesis, one of which is Cutibacterium acnes (C. acnes). Resistance of this bacteria to different antimicrobials used in treatment has been described in different regions of the world. The purpose of the study is to estimate the resistance of C. acnes to cyclins in patients with moderate and severe acne over 18 years of age. An analytical cross-sectional study was carried out. Samples were taken from inflammatory lesions with a comedone extractor. The content of the samples was incubated in an anaerobic atmosphere to grow C. acnes. Finally, the susceptibility of C. acnes to tetracycline, minocycline and doxycycline was determined. Samples were taken from 147 patients, of which 129 showed growth of C. acnes, finding that 5.43% of the strains were resistant to tetracycline, 5.43% to doxycycline, 0.78% to minocycline and cross resistance between doxycycline and tetracycline in all the cases. An association was found between resistance and being 25 years of age or older. No association was found with the prior use of antibiotics, a history of misuse of oral or topical antibiotics, and other demographic and clinical characteristics evaluated. The resistance found of C. acnes to cyclines was lower than that reported in other studies. Although no relationship was found with the previous use of antibiotics, it is a factor described in previous studies, which is why the proper use of antibiotics is imperative to avoid the appearance of resistance. El acné es una enfermedad inflamatoria crónica, en cuya patogenia intervienen diferentes actores, siendo Cutibacterium acnes (C. acnes) uno de ellos. La resistencia de esta bacteria a los diferentes fármacos antimicrobianos utilizados en su tratamiento ha sido descrita en diferentes regiones del mundo. El objetivo de este estudio fue estimar la resistencia de C. acnes a las ciclinas en pacientes mayores de 18 años con acné de moderado a severo. Se realizó un estudio transversal analítico. Se obtuvieron muestras de las lesiones inflamatorias con un extractor de comedones. Se incubó el contenido de las muestras en ambiente anaeróbico para aislar C. acnes. Por último se estimó la susceptibilidad de C. acnes a la tetraciclina, minociclina y doxiciclina. Se obtuvieron muestras de 147 pacientes, observándose crecimiento de C. acnes en 129 de ellos, y encontrándose que el 5,43% de las cepas era resistente a tetraciclina, el 5,43% a doxiciclin