Coronary Diet Intervention with Olive Oil and Cardiovascular Prevention Study (The Cordioprev Study): Rationale, Methods, and Baseline Characteristics

• Published in: The American heart journal 2016-07, Vol.177, p.42-50
• Main Authors: Delgado-Lista, Javier, Perez-Martinez, Pablo, Garcia-Rios, Antonio, Alcala-Diaz, Juan F, Perez-Caballero, Ana I, Gomez-Delgado, Francisco, Fuentes, Francisco, Quintana-Navarro, Gracia, Lopez-Segura, Fernando, Ortiz-Morales, Ana M, Delgado-Casado, Nieves, Yubero-Serrano, Elena, Camargo, Antonio, Marin, Carmen, Rodriguez-Cantalejo, Fernando, Gomez-Luna, Purificacion, Ordovas, Jose M, Lopez-Miranda, Jose, Perez-Jimenez, Francisco
• Format: Article
• Language: English
• Subjects: Cardiovascular
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1016/j.ahj.2016.04.011

Abstract Coronary heart disease (CHD) represents a major global health burden. However, despite the well-known influence that dietary habits exert over the progression of this disease, there are no well-established and scientifically sound dietary approaches to prevent the onset of clinical outcomes in secondary prevention. The objective of the CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (CORDIOPREV study, clinical trials number NCT00924937) is to compare the ability of a Mediterranean diet rich in virgin olive oil versus a low-fat diet to influence the composite incidence of cardiovascular events after 7 years, in subjects with documented CHD at baseline. For this purpose, we enrolled 1002 coronary patients from Spain. Baseline assessment (2009–12) included detailed interviews and measurements to assess dietary, social and biological variables. Results of baseline characteristics: The CORDIOPREV study in Spain describes a population with a high BMI (37.2% overweight and 56.3% obesity), with a median of LDL-cholesterol of 88.5 mg/dL (70.6% of the patients having