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Clinical and molecular epidemiology of community-onset, extended-spectrum β-lactamase-producing Escherichia coli infections in Thailand: A case-case-control study

Background Extended-spectrum β-lactamase (ESBL)-producing organisms, first identified in Germany in 1983, are now widely recognized as clinically relevant causes of infections in community. Methods Our objective was to evaluate the clinical and molecular epidemiology of community-onset, extended-spe...

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Bibliographic Details
Published in:American journal of infection control 2007-11, Vol.35 (9), p.606-612
Main Authors: Apisarnthanarak, Anucha, MD, Kiratisin, Patarachai, MD, PhD, Saifon, Piyawan, BSc, Kitphati, Rungrueng, MD, Dejsirilert, Surang, MSc, Mundy, Linda M., MD
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Language:English
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Summary:Background Extended-spectrum β-lactamase (ESBL)-producing organisms, first identified in Germany in 1983, are now widely recognized as clinically relevant causes of infections in community. Methods Our objective was to evaluate the clinical and molecular epidemiology of community-onset, extended-spectrum β-lactamase (CO-ESBL)-producing Escherichia coli infections. We used a case-case-control study undertaken in a 450-bed, tertiary care hospital. Patients included case group (CG) I, which had confirmed CO-ESBL-producing E coli infections (n = 46). Case group (CG) II (n = 46) included patients with CO-non-ESBL-producing E coli infections. Controls (n = 138) were patients without infections. Results By multivariate analysis, diabetes (95% confidence interval [CI]: 1.9-13.2, P < .001), prior ESBL E coli colonization (
ISSN:0196-6553
1527-3296
DOI:10.1016/j.ajic.2007.05.008