In vitro Activity of Fluoroquinolones, Vancomycin, and Gentamicin Against Methicillin-Resistant Staphylococcus aureus Ocular Isolates

To determine the antibacterial activity of fluoroquinolones, vancomycin, and gentamicin against methicillin-resistant Staphylococcus aureus (MRSA) ocular surface isolates. Retrospective review. MRSA isolates were obtained from 21 patients. The MIC 50 (mean inhibitory concentration)(μg/ml) values of...

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Bibliographic Details
Published in:American journal of ophthalmology 2006-11, Vol.142 (5), p.726-729.e1
Main Authors: Kotlus, Brett S., Wymbs, Richard A., Vellozzi, Ernestine M., Udell, Ira J.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
Fluoroquinolones - pharmacology
Gentamicins - pharmacology
Humans
Medical sciences
Methicillin - pharmacology
Methicillin Resistance
Microbial Sensitivity Tests
Miscellaneous
Ophthalmology
Retrospective Studies
Staphylococcus aureus - drug effects
Staphylococcus aureus - isolation & purification
Vancomycin - pharmacology
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Summary:To determine the antibacterial activity of fluoroquinolones, vancomycin, and gentamicin against methicillin-resistant Staphylococcus aureus (MRSA) ocular surface isolates. Retrospective review. MRSA isolates were obtained from 21 patients. The MIC 50 (mean inhibitory concentration)(μg/ml) values of 31 MRSA ocular surface isolates were determined for gatifloxacin, moxifloxacin, ciprofloxacin, ofloxacin, vancomycin, and gentamicin using the Etest (AB Biodisk, Solna, Sweden) or the VITEK system (bioMérieux, Inc, Durham, North Carolina, USA). Susceptibility data were interpreted based on criteria specified by the Clinical and Laboratory Standards Institute (CLSI). main outcome measures : MIC 50 values in μg/ml and interpretation of susceptibility or resistance. In vitro resistance rates and median MIC 50 in μg/ml for the MRSA isolates were: gatifloxacin (71%, 8.0), moxifloxacin (68%, 8.0), ciprofloxacin (94%, 8.0), ofloxacin (94%, 8.0), vancomycin (0%, 1.0), and gentamicin (3%, 0.5). MRSA ocular isolates exhibited a relatively high rate of in vitro resistance to all fluoroquinolones tested, including the fourth generation. In contrast, MRSA isolates were found to be highly sensitive to vancomycin and gentamicin.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2006.06.030