National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development

The use of illicit and licit drugs during pregnancy is a major public health concern because of potential adverse effects on the fetus and the risk to maternal health. Because the placenta is the primary link between the mother and the conceptus and is essential for the growth and survival of the fe...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2004-12, Vol.191 (6), p.1858-1862
Main Authors: Thadani, Pushpa V., Strauss, Jerome F., Dey, Sudhansu K., Anderson, Virginia M., Audus, Kenneth L., Coats, Karen S., Cross, James C., Erlebacher, Adrian, Ganapathy, Vadivel, Linzer, Daniel I., Miller, Richard K., Novak, Donald A., Rapaka, Rao S., Sadovsky, Yoel, Salafia, Carolyn M., Soares, Michael, Unadkat, Jashvant
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drugs of abuse
Female
Fetal Death
Fetal Development - drug effects
Fetal growth
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Incidence
Maternal-Fetal Exchange
Medical sciences
Placenta
Pregnancy
Pregnancy Complications - epidemiology
Pregnancy Complications - etiology
Pregnancy Outcome
Pregnancy Proteins - metabolism
Pregnancy, High-Risk
Proteins
Risk Assessment
Substance-Related Disorders - complications
Substance-Related Disorders - epidemiology
Substance-Related Disorders - physiopathology
Substance-Related Disorders - prevention & control
Transporters
United States
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Summary:The use of illicit and licit drugs during pregnancy is a major public health concern because of potential adverse effects on the fetus and the risk to maternal health. Because the placenta is the primary link between the mother and the conceptus and is essential for the growth and survival of the fetus, abnormalities in placental formation and function resulting from drug use could have a major influence on pregnancy outcome. At present, little information is available on the impact of abused drugs on placental biology alone or in combination with other “host” factors (eg, stress, infections). This prompted the National Institute on Drug Abuse (NIDA) to convene a meeting of experts in placental biology to review cutting-edge research with the mission to translate existing information to new clinical and research initiatives in the drug abuse field. This report summarizes the presentations and research recommendations resulting from the workshop discussions.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2004.07.059