Dismal outcome of oral squamous cell carcinoma after successful loco-regional control: Distant metastasis to rare sites

The main risk factors for distant metastasis (DM) from oral squamous cell carcinoma (OSCC) are poor loco-regional control, location, T and N stage and histologic grade of the primary tumor. In this paper we present three cases of DM from OSCC that occurred within the first year of treatment despite...

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Bibliographic Details
Published in:Journal of oral and maxillofacial surgery, medicine, and pathology medicine, and pathology, 2014-07, Vol.26 (3), p.324-330
Main Authors: Jayade, Bhushan V., Bhat, Hari Kishore H., Gopal Krishnan, K., Anehosur, Venkatesh, Kumar, Niranjan, Gunari, Prasad P.
Format: Article
Language:English
Subjects:
Distant metastasis
Loco-regional control
Oral squamous cell carcinoma
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Summary:The main risk factors for distant metastasis (DM) from oral squamous cell carcinoma (OSCC) are poor loco-regional control, location, T and N stage and histologic grade of the primary tumor. In this paper we present three cases of DM from OSCC that occurred within the first year of treatment despite radical management of the primary lesion and without any evidence of loco-regional failure. These patients had stage IV lesions in different sites, one in the lip and two in the buccal mucosa with one extending into the alveolus. DM was seen to the lungs, vertebrae and contralateral axillary lymph node. Contralateral axillary node involvement is considered to be uncommon especially from lip carcinoma. After detection of DM all the three patients rapidly deteriorated and succumbed within an average period of 4 months.
ISSN:2212-5558
2212-5566
DOI:10.1016/j.ajoms.2012.12.010