Cyanamide-induced oral lichenoid drug reaction: Case report and literature review

Cyanamide, is an inhibitor of aldehyde dehydrogenase, is widely used in patients with alcoholism. Although cyanamide is a causative drug for drug eruptions, mucosal adverse events of cyanamide have rarely been reported. Here, we report a case of cyanamide-induced oral lichenoid lesion. A 70-year-old...

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Bibliographic Details
Published in:Journal of oral and maxillofacial surgery, medicine, and pathology medicine, and pathology, 2022-03, Vol.34 (2), p.209-212
Main Authors: Akiyama, Yurie, Oomura, Yusuke, Okamura, Masahiro, Hiraga-Kondo, Chiho, Suzuki, Taiki, Sato, Kazumichi, Takahashi, Shinichi, Nomura, Takeshi
Format: Article
Language:English
Subjects:
Cyanamide
Oral lichenoid drug reactions
Oral lichenoid lesions
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Summary:Cyanamide, is an inhibitor of aldehyde dehydrogenase, is widely used in patients with alcoholism. Although cyanamide is a causative drug for drug eruptions, mucosal adverse events of cyanamide have rarely been reported. Here, we report a case of cyanamide-induced oral lichenoid lesion. A 70-year-old man was admitted to the hospital because of the presence of oral lesions and difficulty in swallowing. He was taking cyanamide for the treatment of chronic alcoholism. The oral lichenoid lesions appeared one month after the initiation of cyanamide. The drug lymphocyte stimulation test for cyanamide was negative, while the patch test for cyanamide was positive. The symptoms improved 18 days after the discontinuation of cyanamide. A review of the literature has only 2 reports of cyanamide-induced lichenoid lesions with and/or without skin manifestations.
ISSN:2212-5558
2212-5566
DOI:10.1016/j.ajoms.2021.09.005