A low-grade dedifferentiated mucoepidermoid carcinoma of the retromolar trigone: A rare case report

Dedifferentiation is a rare phenomenon in mucoepidermoid carcinoma (MEC), and it has not been observed in the minor salivary glands. We describe the case of a 22-year-old woman with dedifferentiated MEC that originated in the retromolar glands. We performed tumor excision, and histopathological exam...

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Bibliographic Details
Published in:Journal of oral and maxillofacial surgery, medicine, and pathology medicine, and pathology, 2022-07, Vol.34 (4), p.547-552
Main Authors: Todoroki, Keita, Abe, Yushi, Kikuta, Shogo, Shinozaki, Katsumi, Nakamura, Moriyoshi, Kusukawa, Jingo
Format: Article
Language:English
Subjects:
Dedifferentiated mucoepidermoid carcinoma
Dedifferentiation
Heavy particle therapy
Low-grade dedifferentiation
Mucoepidermoid carcinoma
Retromolar gland
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Summary:Dedifferentiation is a rare phenomenon in mucoepidermoid carcinoma (MEC), and it has not been observed in the minor salivary glands. We describe the case of a 22-year-old woman with dedifferentiated MEC that originated in the retromolar glands. We performed tumor excision, and histopathological examination revealed dedifferentiated MEC based on FISH-based analysis of MAML2 gene rearrangement. The manner of dedifferentiation in our case was slightly different from that in MEC reported previously, and it was considered “low-grade” dedifferentiation. In 3.75 years since the surgery, the tumor has recurred locally twice, and in both cases, a good response to heavy-particle irradiation was achieved. The patient is still alive, and local control has been maintained.
ISSN:2212-5558
2212-5566
DOI:10.1016/j.ajoms.2022.01.009