The effect of cannabinoid CB1 receptor antagonist rimonabant (SR-141716) on ethanol drinking in high-preferring rats

Abstract The present study investigated the effect of the cannabinoid CB1 receptor antagonist, rimonabant (SR-141716) on ethanol intake in selectively bred alcohol-preferring Warsaw High-Preferring rats. Ethanol (10% vol/vol) and food were available in daily 4-h limited access period while water was...

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Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2008-09, Vol.42 (6), p.509-512
Main Authors: Dyr, Wanda, Ligięza, Janusz, Kostowski, Wojciech
Format: Article
Language:English
Subjects:
Psychiatry
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Summary:Abstract The present study investigated the effect of the cannabinoid CB1 receptor antagonist, rimonabant (SR-141716) on ethanol intake in selectively bred alcohol-preferring Warsaw High-Preferring rats. Ethanol (10% vol/vol) and food were available in daily 4-h limited access period while water was available ad libitum. The administration (i.p.) of single 2.5 and 5.0-mg/kg doses of rimonabant preferentially reduced ethanol intake, whereas a 10 mg/kg dose of rimonabant similarly reduced both ethanol and food intake. Our result extends the suppressive effect of cannabinoid CB1 receptor antagonist to the ethanol drinking behavior in Warsaw High-Preferring line of rats. The result also supports a growing body of literature indicating that the cannabinoid CB1 receptor is involved in motivational and appetitive properties of ethanol.
ISSN:0741-8329
DOI:10.1016/j.alcohol.2008.04.001