Update on sesquiterpenes from red macroalgae of the Laurencia genus and their biological activities (2015–2020)

• Published in: Algal research (Amsterdam) 2021-06, Vol.56, p.102330, Article 102330
• Main Authors: Cikoš, Ana-Marija, Jurin, Mladenka, Čož-Rakovac, Rozelindra, Gašo-Sokač, Dajana, Jokić, Stela, Jerković, Igor
• Format: Article
• Language: English
• Subjects: Bioactive compounds (cytotoxic, anti-inflammatory, antibacterial, antifungal, antidiabetic, anthelmintic, others); Laurencia genus; Macroalgae; Marine natural products (different sesquiterpene skeletons)
• ISSN: 2211-9264; 2211-9264
• DOI: 10.1016/j.algal.2021.102330

Laurencia genus has been the most promising source of sesquiterpenes (among all macroalgae) including those with high degree of halogenation, especially bromination. Related published reviews do not report novel researches included in this study and are not focused exclusively on this genus or sesquiterpenes. The present review reports novel structures of Laurencia derived sesquiterpenes exclusively in the period of 2015–2020, with emphasis on their structural diversity and different skeleton types including chemical biomarkers along with the methods for their structural analysis. Their cytotoxic, anti-inflammatory, antibacterial, antifungal, antidiabetic, anthelmintic activities and others are summarised indicating determined structure – activity relationships along with ecological role of targeted sesquiterpenes. Furthermore, possible stages of sesquiterpene biosynthesis are presented for better understanding of their chemodiversity. [Display omitted] •Unique and chemodiverse sesquiterpenes from Laurencia genus (2015–2020)•Different skeletons: chamigrane, cuparane, laurane, bisabolane, eudesmane, aristolane others•Cytotoxic, anti-inflammatory, antimicrobial, antidiabetic, and other activities•Proposed stages of sesquiterpene biosynthesis