A comparative study of metabolites profiles, anti-inflammatory and antioxidant activity of methanolic extracts from three Arthrospira strains in RAW 264.7 macrophages

Arthrospira (spirulina), is a cyanobacterium endowed with antioxidant and anti-inflammatory activity, but strain-dependent production of bioactive compounds may impact these properties. In LPS-stimulated RAW 264.7 macrophages, we compared the antioxidant and anti-inflammatory activity of methanolic...

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Bibliographic Details
Published in:Algal research (Amsterdam) 2023-06, Vol.73, p.103171, Article 103171
Main Authors: Bigagli, Elisabetta, D'Ambrosio, Mario, Cinci, Lorenzo, Pieraccini, Giuseppe, Romoli, Riccardo, Biondi, Natascia, Niccolai, Alberto, Rodolfi, Liliana, Tredici, Mario R., Luceri, Cristina
Format: Article
Language:English
Subjects:
Arthrospira
Carotenoids
Glycolipids
Inflammation
Microalgae
Spirulina
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Summary:Arthrospira (spirulina), is a cyanobacterium endowed with antioxidant and anti-inflammatory activity, but strain-dependent production of bioactive compounds may impact these properties. In LPS-stimulated RAW 264.7 macrophages, we compared the antioxidant and anti-inflammatory activity of methanolic extracts from two A. platensis (F&M-C256 and F&M-C260), and an A. maxima (F&M-C258) strains. F&M-C260 (5–25 μg/mL) concentration dependently inhibited LPS-induced NO release (p 
ISSN:2211-9264
2211-9264
DOI:10.1016/j.algal.2023.103171