Optimal Vitamin D Status for Colorectal Cancer Prevention

Background Previous studies, such as the Women’s Health Initiative, have shown that a low dose of vitamin D did not protect against colorectal cancer, yet a meta-analysis indicates that a higher dose may reduce its incidence. Methods Five studies of serum 25(OH)D in association with colorectal cance...

Full description

Saved in:
Bibliographic Details
Published in:American journal of preventive medicine 2007, Vol.32 (3), p.210-216
Main Authors: Gorham, Edward D., MPH, PhD, Garland, Cedric F., DrPH, Garland, Frank C., PhD, Grant, William B., PhD, Mohr, Sharif B., MPH, Lipkin, Martin, MD, Newmark, Harold L., ScD, Giovannucci, Edward, MD, ScD, Wei, Melissa, BS, Holick, Michael F., MD, PhD
Format: Article
Language:English
Subjects:
Internal Medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Previous studies, such as the Women’s Health Initiative, have shown that a low dose of vitamin D did not protect against colorectal cancer, yet a meta-analysis indicates that a higher dose may reduce its incidence. Methods Five studies of serum 25(OH)D in association with colorectal cancer risk were identified using PubMed. The results of all five serum studies were combined using standard methods for pooled analysis. The pooled results were divided into quintiles with median 25(OH)D values of 6, 16, 22, 27, and 37 ng/mL. Odds ratios were calculated by quintile of the pooled data using Peto’s Assumption-Free Method, with the lowest quintile of 25(OH)D as the reference group. A dose–response curve was plotted based on the odds for each quintile of the pooled data. Data were abstracted and analyzed in 2006. Results Odds ratios for the combined serum 25(OH)D studies, from lowest to highest quintile, were 1.00, 0.82, 0.66, 0.59, and 0.46 ( ptrend
ISSN:0749-3797
1873-2607
DOI:10.1016/j.amepre.2006.11.004