Evaluating STC-1 and STC-2 mRNA expressions in Schizophrenia patients with increased oxidative stress

Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they...

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Bibliographic Details
Published in:Annales médico psychologiques 2024-11, Vol.182 (9), p.785-790
Main Authors: Karabulut Uzunçakmak, Sevgi, Özcan, Halil, Dirican, Ebubekir, Tavacı Özçelik, Ayşegül
Format: Article
Language:English
Subjects:
Oxidative stress
Schizophrenia
Schizophrénie
Stanniocalcin
Stanniocalcine
STC-1
STC-2
Stress oxydatif
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Summary:Schizophrenia is a chronic psychiatric disorder characterized by cognitive impairment. Oxidative stress is associated with disease progression in patients with schizophrenia. Stanniocalcin (STC)-1 and STC-2 are two proteins commonly expressed in mammals belonging to the stanniocalcin family and they are involved in oxidative stress. The aim of this study is to investigate STC-1 and STC-2 mRNA expressions in schizophrenia patients with altered oxidative stress parameters. For this purpose, 70 patients with schizophrenia and 40 healthy individuals were recruited for the study. Peripheral blood samples were obtained from all participants. Glutathione (GSH) activities, superoxide dismutase (SOD) activities, and malondialdehyde (MDA) levels were measured. STC-1 and STC-2 expressions were assessed by real-time polymerase chain reactions. SOD activity levels were lower in patients than in healthy individuals (p=0.0309), while the patients’ MDA levels were higher (p=0.039). STC-1 and STC-2 expressions were lower in patients than in healthy individuals (p=0.1049 and p
ISSN:0003-4487
DOI:10.1016/j.amp.2023.02.005