Ketamine-like Effects After Recreational Use of Methoxetamine

Methoxetamine, the N -ethyl derivative of ketamine, is a novel recreational drug that is not at present subject to restrictive regulations in most countries. To our knowledge, no case of methoxetamine abuse has been published to date in the scientific literature, and the only sources of information...

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Bibliographic Details
Published in:Annals of emergency medicine 2012-07, Vol.60 (1), p.97-99
Main Authors: Hofer, Katharina E., MD, Grager, Bettina, MD, Müller, Daniel M., MSc, Rauber-Lüthy, Christine, MD, Kupferschmidt, Hugo, MD, Rentsch, Katharina M., PhD, Ceschi, Alessandro, MD
Format: Article
Language:English
Subjects:
Anesthetics, Dissociative - adverse effects
Confusion - chemically induced
Cyclohexanones - poisoning
Cyclohexylamines - poisoning
Dyskinesias - etiology
Emergency
Humans
Hypertension - chemically induced
Ketamine - adverse effects
Male
Mydriasis - chemically induced
Nystagmus, Pathologic - chemically induced
Street Drugs - poisoning
Tachycardia - chemically induced
Young Adult
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Summary:Methoxetamine, the N -ethyl derivative of ketamine, is a novel recreational drug that is not at present subject to restrictive regulations in most countries. To our knowledge, no case of methoxetamine abuse has been published to date in the scientific literature, and the only sources of information are illegal drug users' Web discussion forums. We report the first case of analytically confirmed intravenous methoxetamine abuse in a 19-year-old man. Observed signs and symptoms such as tachycardia, hypertension, confusion, agitation, stupor, ataxia, mydriasis, and nystagmus were consistent with ketamine-induced adverse effects and resolved with symptomatic treatment. According to this case report, user Web reports, and the chemical structure, methoxetamine produces ketamine-like effects. Complete recovery can be expected with supportive care.
ISSN:0196-0644
1097-6760
DOI:10.1016/j.annemergmed.2011.11.018