Trisomy 4 associated with double minute chromosomes and MYC amplification in acute myeloblastic leukemia

A case of de novo acute myeloblastic leukemia (AML) M2, with trisomy 4 and double minute (dmin) chromosomes is reported. Amplification of the MYC gene ascertained by FISH was associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that this entity preferentially occur...

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Bibliographic Details
Published in:Annales de génétique 2004-10, Vol.47 (4), p.423-427
Main Authors: Receveur, Aline, Ong, Jeanne, Merlin, Laurent, Azgui, Zahia, Merle-Béral, Hélène, Berger, Roland, Nguyen-Khac, Florence
Format: Article
Language:English
Subjects:
Age Factors
Aged
Asthenia
Biological and medical sciences
Chromosome aberrations
Chromosomes, Human, Pair 4
Double minute
Female
Gene Amplification
General aspects. Genetic counseling
Genes, myc
Hematologic and hematopoietic diseases
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemia, Myeloid, Acute - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical genetics
Medical sciences
MYC
Sex Factors
Trisomy - genetics
Trisomy 4
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Summary:A case of de novo acute myeloblastic leukemia (AML) M2, with trisomy 4 and double minute (dmin) chromosomes is reported. Amplification of the MYC gene ascertained by FISH was associated with dmin. A review of the literature of trisomy 4-dmin-associated AML shows that this entity preferentially occurs in elderly women and is not always associated with previously identified exposition to mutagens.
ISSN:0003-3995
DOI:10.1016/j.anngen.2004.08.004