Natural progression of premature pubarche and underlying diseases

Premature pubarche (PP) is generally thought to be a benign condition, but it can also be the first sign of underlying disease. To analyse the aetiology and the evolution of the anthropometric, analytical and metabolic risk parameters of a group of patients with PP. A descriptive and analytical retr...

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Bibliographic Details
Published in:Anales de Pediatría 2018-10, Vol.89 (4), p.238-245
Main Authors: Sancho Rodríguez, María Luisa, Bueno Lozano, Gloria, Labarta Aizpún, José Ignacio, de Arriba Muñoz, Antonio
Format: Article
Language:English
Subjects:
Adrenarquia prematura idiopática
Hiperplasia suprarrenal congénita no clásica
Idiopathic premature adrenarche
Non-classic congenital adrenal hyperplasia
Premature pubarche
Pubarquia precoz
Pubertad
Puberty
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Summary:Premature pubarche (PP) is generally thought to be a benign condition, but it can also be the first sign of underlying disease. To analyse the aetiology and the evolution of the anthropometric, analytical and metabolic risk parameters of a group of patients with PP. A descriptive and analytical retrospective study of 92 patients affected by PP. Anthropometry, analyses, bone age and indicators of lipid metabolism were all evaluated. The sample included 92 patients with PP (67 female and 25 male), with a mean age of 7.1±0.6 for girls and 8.3±0.7 for boys. Small for gestational age was recorded in 7.7%. There was an accelerated bone age (1.20±0.1 years). A total of 21 patients were classified as idiopathic (23%), 60 as idiopathic premature adrenarche (65%), and 11 with non-classic congenital adrenal hyperplasia (12%). Puberty was reached early (11+0.9 years old in boys and 9.9±0.8 in girls), as was menstruation age (11.8+1.1 years old), P
ISSN:2341-2879
2341-2879
DOI:10.1016/j.anpede.2018.08.003