Invasive meningococcal disease in children and adults in a tertiary level hospital. Recent epidemiology and prognostic factors

Invasive meningococcal disease (IMD) has a high morbidity and mortality in children and adults. The aim of this study was to describe the clinical and epidemiological characteristics of patients with IMD, to compare them among children and adults, and to determine prognostic factors and changes in e...

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Published in:Anales de Pediatría 2019-11, Vol.91 (5), p.296-306
Main Authors: Maturana Martínez, Daniela, Aguilera-Alonso, David, García Mancebo, Julia, Navarro, María Luisa, Hernández Sampelayo, Teresa, Rincón López, Elena María, Santiago-García, Begoña, Saavedra-Lozano, Jesús, Santos, Mar, Cercenado, Emilia
Format: Article
Language:English
Subjects:
Epidemiology
Epidemiología
Meningitis
Morbidity
Morbilidad
Neisseria meningitidis
Sepsis
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Summary:Invasive meningococcal disease (IMD) has a high morbidity and mortality in children and adults. The aim of this study was to describe the clinical and epidemiological characteristics of patients with IMD, to compare them among children and adults, and to determine prognostic factors and changes in epidemiology during a 14-year period. A retrospective study was conducted on patients admitted to a third level hospital with IMD between 2004 and 2017. An analysis was made of the clinical, epidemiological and microbiological data. A total of 84 patients were diagnosed with IMD, of which 50 (59.5%) were children. Median age was 2 years (IQR 0.7–7.5) for children and 41.2 years (IQR 26.4–69.3) for adults. Diagnosis was bacteraemia in 47 patients (56%), meningitis in 24 (28.6%), and both in 13 (15.5%). Serogroup B (MenB) was the most common cause of IMD (40.5%), followed by serogroup C (MenC) in 15.5%, which was more common among adults (26.5% vs 8%, P=.022). Incidence rate decreased between 2004–2010 and 2011–2017, from 3.14 to 1.33cases/100000 emergencies attended in the study hospital (P
ISSN:2341-2879
2341-2879
DOI:10.1016/j.anpede.2019.09.001