Serogroup C invasive meningococcal disease in the post-vaccine era and vaccine failures

The incidence of serogroup C invasive meningococcal disease (IMD) has decreased since the introduction of systematic vaccination in 2000 The aim of this study is to determine the number serogroup C IMD cases diagnosed since then and the vaccine failures. A retrospective analysis was performed on pat...

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Bibliographic Details
Published in:Anales de Pediatría 2020-12, Vol.93 (6), p.396-402
Main Authors: Rius, Neus, Lung, Mayli, Fernández-San José, Carolina, Iglesias, Tamara, Esperalba, Juliana, Moraga-Llop, Fernado A., Soler-Palacín, Pere
Format: Article
Language:eng ; spa
Subjects:
Enfermedad meningocócica invasiva
Epidemiology
Epidemiología
Fallo vacunal
Invasive meningococcal disease
Meningitis C conjugated vaccine
Meningococo serogrupo B
Meningococo serogrupo C
Polymerase chain reaction
Reacción en cadena de la polimerasa
Serogroup B meningococcus
Serogroup C meningococcus
Vaccine failure
Vacuna conjugada antimeningocócica C
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Summary:The incidence of serogroup C invasive meningococcal disease (IMD) has decreased since the introduction of systematic vaccination in 2000 The aim of this study is to determine the number serogroup C IMD cases diagnosed since then and the vaccine failures. A retrospective analysis was performed on patients diagnosed with IMD by culture or polymerase chain reaction (PCR) in a maternity and childhood hospital in Barcelona between 2001 and 2018. An analysis was made of the number of vaccine doses and the age received, as well as on the medical records and vaccine cards. There were 128 confirmed cases of IMD (7.1 cases/year; 70.3 in
ISSN:2341-2879
2341-2879
DOI:10.1016/j.anpede.2020.02.005