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Lubricating adhesive hyaluronate patch promotes cartilage regeneration and functional restoration in osteoarthritis

•Phenolic hyaluronate patch exhibits excellent mechanical and adhesive properties.•The patch possesses lubricating and free radical-scavenging ability.•The patch prolongs therapeutic effects via sustained drug release.•The patch promotes cartilage regeneration and functional recovery in osteoarthrit...

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Published in:Applied materials today 2024-08, Vol.39, p.102318, Article 102318
Main Authors: Choi, Soojeong, Jeon, Eun Je, Bae, Yunsu, Jeon, Jihoon, Kang, Donyoung, Lee, Hyungsuk, Cho, Seung-Woo
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container_title Applied materials today
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creator Choi, Soojeong
Jeon, Eun Je
Bae, Yunsu
Jeon, Jihoon
Kang, Donyoung
Lee, Hyungsuk
Cho, Seung-Woo
description •Phenolic hyaluronate patch exhibits excellent mechanical and adhesive properties.•The patch possesses lubricating and free radical-scavenging ability.•The patch prolongs therapeutic effects via sustained drug release.•The patch promotes cartilage regeneration and functional recovery in osteoarthritis. Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by gradual deterioration and pain. Viscosupplementation, involving hyaluronic acid (HA) injection into the affected joint, is a minimally invasive option to reduce pain by improving joint lubrication and potentially avoiding the need for replacement surgery. However, the low adhesion and rapid degradation of HA often lead to inadequate therapeutic effects. In this study, we present lubricating adhesive HA-based hydrogel patches designed to effectively treat OA. The HA patches, modified with pyrogallol, have high elastic and compressive moduli, delaying degradation when exposed to external stimuli. Furthermore, they securely adhere to cartilage tissue surfaces and efficiently lubricate damaged cartilage, leading to a reduced friction and wear. In addition to these benefits, our HA patches exhibit scavenging effect of reactive oxygen species and sustainably release an encapsulated anti-inflammatory drug (dexamethasone: Dex). These features further enhance their therapeutic potential for OA treatment. In a mouse OA model, the hydrogel patches loaded with Dex promote healing of damaged cartilage and restore its motor function. Overall, our bioinspired HA hydrogel patches present a promising treatment option for managing the debilitating joint disease by offering enhanced adhesion, lubrication for cartilage protection, antioxidant effect, and sustained drug release. [Display omitted]
doi_str_mv 10.1016/j.apmt.2024.102318
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Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by gradual deterioration and pain. Viscosupplementation, involving hyaluronic acid (HA) injection into the affected joint, is a minimally invasive option to reduce pain by improving joint lubrication and potentially avoiding the need for replacement surgery. However, the low adhesion and rapid degradation of HA often lead to inadequate therapeutic effects. In this study, we present lubricating adhesive HA-based hydrogel patches designed to effectively treat OA. The HA patches, modified with pyrogallol, have high elastic and compressive moduli, delaying degradation when exposed to external stimuli. Furthermore, they securely adhere to cartilage tissue surfaces and efficiently lubricate damaged cartilage, leading to a reduced friction and wear. In addition to these benefits, our HA patches exhibit scavenging effect of reactive oxygen species and sustainably release an encapsulated anti-inflammatory drug (dexamethasone: Dex). These features further enhance their therapeutic potential for OA treatment. In a mouse OA model, the hydrogel patches loaded with Dex promote healing of damaged cartilage and restore its motor function. Overall, our bioinspired HA hydrogel patches present a promising treatment option for managing the debilitating joint disease by offering enhanced adhesion, lubrication for cartilage protection, antioxidant effect, and sustained drug release. 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Osteoarthritis (OA) is a common chronic degenerative joint disease characterized by gradual deterioration and pain. Viscosupplementation, involving hyaluronic acid (HA) injection into the affected joint, is a minimally invasive option to reduce pain by improving joint lubrication and potentially avoiding the need for replacement surgery. However, the low adhesion and rapid degradation of HA often lead to inadequate therapeutic effects. In this study, we present lubricating adhesive HA-based hydrogel patches designed to effectively treat OA. The HA patches, modified with pyrogallol, have high elastic and compressive moduli, delaying degradation when exposed to external stimuli. Furthermore, they securely adhere to cartilage tissue surfaces and efficiently lubricate damaged cartilage, leading to a reduced friction and wear. 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subjects Adhesive phenolic hyaluronic acid
Lubricating hydrogel patch
Osteoarthritis
ROS scavenging
Sustained drug delivery
title Lubricating adhesive hyaluronate patch promotes cartilage regeneration and functional restoration in osteoarthritis
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