Capsaicin increases sensation of fullness in energy balance, and decreases desire to eat after dinner in negative energy balance

• Published in: Appetite 2014-06, Vol.77, p.46-51
• Main Authors: Janssens, Pilou L.H.R., Hursel, Rick, Westerterp-Plantenga, Margriet S.
• Format: Article
• Language: English
• Subjects: ad libitum intake; Adolescent; Adult; Appetite - drug effects; Appetite profile; Capsaicin; Capsaicin - pharmacology; Capsicum - chemistry; Diet; Eating - drug effects; Energy balance; Energy Intake - drug effects; Energy Metabolism; Feeding Behavior - drug effects; Female; Fullness; Humans; Hunger; Hyperphagia - prevention & control; Male; Meals; Middle Aged; Obesity - prevention & control; Satiation - drug effects; Satiety Response - drug effects; Sensation; Single-Blind Method; Young Adult
• ISSN: 0195-6663; 1095-8304
• DOI: 10.1016/j.appet.2014.02.018

•In energy balance, addition of capsaicin to the diet increases satiety and fullness.•Addition of capsaicin to the diet tends to prevent overeating in energy balance.•In negative energy balance, capsaicin decreases desire to eat after dinner. Addition of capsaicin (CAPS) to the diet has been shown to increase satiety; therefore, CAPS is of interest for anti-obesity therapy. We investigated the effects of CAPS on appetite profile and ad libitum energy intake in relation to energy balance. Fifteen subjects (seven women and eight men, age: 29.7 ± 10.8yrs, BMI: 23.3 ± 2.9 kg/m2) underwent four conditions in a randomized crossover design in 36 hour sessions in a respiration chamber; they received 100% of their daily energy requirements in the conditions “100%Control” and “100%CAPS”, and 75% of their daily energy requirements in the conditions “75%Control” and “75%CAPS”, followed by an ad libitum dinner. In the 100%CAPS and 75%CAPS conditions, CAPS was given at a dose of 2.56 mg (1.03 g of red chili pepper, 39,050 Scoville heat units) with every meal. Satiety (P