Leptin as a cardiovascular risk marker in metabolically healthy obese

• Published in: Appetite 2017-01, Vol.108, p.477-482
• Main Authors: Jamar, Giovana, Caranti, Danielle Arisa, de Cassia Cesar, Helena, Masquio, Deborah Cristina Landi, Bandoni, Daniel Henrique, Pisani, Luciana Pellegrini
• Format: Article
• Language: English
• Subjects: Adipokines; Healthy; Hyperleptinemia; Metabolic obesity
• ISSN: 0195-6663; 1095-8304
• DOI: 10.1016/j.appet.2016.11.013

Adipokines contribute to the inflammatory process which can lead to obesity-associated cardiometabolic complications. Metabolically healthy obese individuals seem to be protected or more resistant to develop these complications and it is intriguing why some individuals develop comorbidities and others do not. Thus, we questioned whether the differences between metabolically healthy and unhealthy obese relied on the alterations in metabolic profile, characterized by serum leptin and adiponectin. A total of 142 obese adults were divided into 2 groups – metabolically healthy obese (MHO) or unhealthy obese (MUO) – and they were evaluated for anthropometric measures, body composition, blood pressure, dietary intakes and plasma levels of leptin and adiponectin. Leptin/adiponectin ratio (L/A) was calculated. Age, BMI and blood pressure were higher in the MUO. No differences in anthropometric measurements, body composition, dietary intake and dietary quality were observed between groups. Leptin were significantly higher in the MUO (53.07 ± 34.56 versus 36.27 ± 24.02 ng/ml in the MHO, r