Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment

Genetic differential susceptibility states that individuals may vary both by exhibiting poor responses when exposed to adverse environments, and disproportionally benefiting from positive settings. The dopamine D4 receptor gene (DRD4) may be particularly implicated in these effects, including distur...

Full description

Saved in:
Bibliographic Details
Published in:Appetite 2020-05, Vol.148, p.104594, Article 104594
Main Authors: Barth, Barbara, Bizarro, Lisiane, Miguel, Patrícia Maidana, Dubé, Laurette, Levitan, Robert, O'Donnell, Kieran, Meaney, Michael J., Silveira, Patricia Pelufo
Format: Article
Language:English
Subjects:
Adult
Child Behavior - psychology
Child Development
Child, Preschool
Cohort Studies
Differential susceptibility
DRD4
Eating - genetics
Eating - psychology
Emotional eating
Emotions
Family Conflict
Feeding Behavior - psychology
Female
Gene Expression
Genetic Predisposition to Disease
Humans
Hyperphagia
Infant
Infant, Newborn
Machine Learning
Male
Mother-Child Relations
Mothers
Obesity - etiology
Obesity - genetics
Obesity - metabolism
Receptors, Dopamine D4 - genetics
Receptors, Dopamine D4 - metabolism
Singapore
Social Environment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Genetic differential susceptibility states that individuals may vary both by exhibiting poor responses when exposed to adverse environments, and disproportionally benefiting from positive settings. The dopamine D4 receptor gene (DRD4) may be particularly implicated in these effects, including disturbed eating behaviors that might lead to obesity. Here, we explore differential susceptibility to positive environments according to the predicted genetically regulated gene expression of prefrontal cortex DRD4 gene. Using MAVAN as the discovery cohort (Maternal Adversity, Vulnerability and Neurodevelopment) and GUSTO as the replication cohort (Growing Up in Singapore Towards Healthy Outcomes), we analyzed the interaction between a) a Positive postnatal environmental score, that accounts for positive outcomes in the postnatal period and b) the genetically regulated gene expression of prefrontal DRD4, computed using a machine learning prediction method (PrediXcan). The outcome measures were the pro-intake domains (Emotional over-eating, Food Responsiveness, Food Enjoyment and Desire to Drink) from the Child Eating Behavior Questionnaire at 48 months of age (MAVAN) and 60 months of age (GUSTO). The interaction between the positive environment and the predicted prefrontal DRD4 gene expression was significant for emotional over-eating in MAVAN (β = −0.403, p 
ISSN:0195-6663
1095-8304
DOI:10.1016/j.appet.2020.104594