Scintigraphic imaging of Staphylococcus aureus infection using 99mTc radiolabeled aptamers

Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful tr...

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Bibliographic Details
Published in:Applied radiation and isotopes 2017-10, Vol.128, p.22-27
Main Authors: Santos, Sara Roberta dos, de Sousa Lacerda, Camila Maria, Ferreira, Iêda Mendes, de Barros, André Luís Branco, Fernandes, Simone Odília, Cardoso, Valbert Nascimento, de Andrade, Antero Silva Ribeiro
Format: Article
Language:English
Subjects:
Aptamer
Bacterial infection
Diagnosis
Radiopharmaceutical
Technetium-99m
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Summary:Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful treatment. Scintigraphy could contribute to this purpose since specific radiotracers were available. Aptamers due to their high specificity have great potential for radiopharmaceuticals development. In the present study scintigraphic images of S. aureus infectious foci were obtained using specific S. aureus aptamers radiolabeled with 99mTc. •99mTc radiolabeled S. aureus aptamers were evaluated for infection imaging.•Identification of S. aureus infected areas was possible by scintigraphic images.•High target to non-target ratios were obtained using the 99mTc radiolabeled aptamers.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2017.06.043