Multilayered polyelectrolyte structures with potential for intracavity drug delivery systems

• Published in: Applied surface science 2019-11, Vol.493, p.620-627
• Main Authors: Exner, Ginka, Marudova, Maria, Sotirov, Sotir, Marinova, Antoaneta, Viraneva, Asya, Pilicheva, Bissera, Bodurov, Ivan, Vlaeva, Ivanka, Uzunova, Yordanka, Yovcheva, Temenuzhka
• Format: Article
• Language: English
• Subjects: Benzydamine hydrochloride; Biopolymers; Drug delivery systems; Multilayered structures; Polyelectrolytes; Self-assembly
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2019.07.039

A design of multilayered polyelectrolyte structures consisting of a substrate of poly-dl-lactide film covered with multilayers of chitosan and casein is reported. An innovative method of corona pretreatment of the substrate was used to ensure the required substrate surface excess charge for the electrostatic attachment of the polyelectrolytes on it. The number of layers was varied from 4 to 16 and the ability of the system to load drugs and to adhere to the buccal mucosa was investigated by means of UV-VIS-NIR spectroscopy, atomic force microscopy, and the small sessile drop technique. At the particular pH and ionic strength used, the optimal number of layers is 8, which results from the loose morphology and complex nature of multilayered structural formation. The drug release is accompanied by polyelectrolyte dissolution. Drug release from multilayered polyelectrolyte structures, composed of poly-DL-lactide substrate and multilayers of casein/chitosan, loaded with benzydamine hydrochloride, estimated from UV-ViS-NIR at 306 nm. [Display omitted] •Multilayered polyelectrolyte structures were built from chitosan/casein onto poly-dl-lactide.•The structures accommodate successfully the model drug benzydamine hydrochloride.•The morphology and the adhesive properties depend on the number of layers.•The optimal number of layers for the particular structures is 8.