Synthesis and characterization of perovskite type of La1-xBaxMnO3 nanoparticles with investigation of biological activity

[Display omitted] •La1-xBaxMnO3 nanoparticles were produced with different stoichiometric ratios of La and Ba.•The biological activity of perovskite type La1-xBaxMnO3 nanoparticle was studied.•La0.6Ba0.4MnO3 showed the highest DPPH free radical scavenging activity (67.23%).•All tested lanthanum nano...

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Bibliographic Details
Published in:Advanced powder technology : the international journal of the Society of Powder Technology, Japan Japan, 2022-01, Vol.33 (1), p.103346, Article 103346
Main Authors: Gonca, Serpil, Özdemir, Sadin, Tekgül, Atakan, Gokhan Unlu, Cumhur, Ocakoglu, Kasim, Dizge, Nadir
Format: Article
Language:English
Subjects:
Antimicrobial
Antioxidant
DNA cleavage
Lanthanum nanoparticles
Perovskite
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Summary:[Display omitted] •La1-xBaxMnO3 nanoparticles were produced with different stoichiometric ratios of La and Ba.•The biological activity of perovskite type La1-xBaxMnO3 nanoparticle was studied.•La0.6Ba0.4MnO3 showed the highest DPPH free radical scavenging activity (67.23%).•All tested lanthanum nanoparticles showed good chemical nuclease activity.•La0.7Ba0.3MnO3 exhibited the highest biofilm inhibition against P. aeruginosa. The enhanced biological activity of perovskite type La1-xBaxMnO3 (x = 0.2, 0.3, 0.4) nanoparticle was studied based on antioxidant, antimicrobial, anti-biofilm, bacterial viability inhibition, and DNA cleavage studies. The nanoparticles were prepared by Sol-gel technique and they were analyzed on structure and morphological by XRD and SEM. La0.6Ba0.4MnO3 showed the highest DPPH free radical scavenging activity and iron chelating activity as 67.23% and 46.54%, respectively. All tested lanthanum nanoparticles showed good chemical nuclease activity. C. tropicalis was the most affected species by lanthanum nanoparticles and MIC values were 4 µg/mL, 8 µg/mL, and 16 µg/mL for La0.7Ba0.4MnO3, La0.6Ba0.4MnO3, and La0.8Ba0.2MnO3, respectively. La0.7Ba0.4MnO3 exhibited the highest percentage of biofilm inhibition against P. aeruginosa and S. aureus as 99.78% and 98.38%, respectively. Cell viability assay demonstrated that La0.7Ba0.4MnO3, La0.6Ba0.4MnO3, and La0.8Ba0.2MnO3 showed %100 cell viability inhibition after 30 and 60 min treatment.
ISSN:0921-8831
1568-5527
DOI:10.1016/j.apt.2021.10.038