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Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Human Neutrophil Activation

[Display omitted] Some pro-inflammatory lipids derived from 1 lipooxygenase enzyme are potent neutrophil chemoattractant, a cell centrally involved in acute respiratory distress syndrome (ARDS); a syndrome lacking effective treatment. Considering the beneficial effects of the leukotriene receptor in...

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Published in:Archivos de bronconeumología (English ed.) 2019-11, Vol.55 (11), p.573-580
Main Authors: Davino-Chiovatto, Jaime Eduardo, Oliveira-Junior, Manoel Carneiro, MacKenzie, BreAnne, Santos-Dias, Alana, Almeida-Oliveira, Ana Roberta, Aquino-Junior, Jefferson Comin Jonco, Brito, Auriléia Aparecida, Rigonato-Oliveira, Nicole Cristine, Damaceno-Rodrigues, Nilsa Regina, Oliveira, Ana Paula Ligeiro, Silva, Alessandro Pereira, Consolim-Colombo, Fernanda Marciano, Aimbire, Flavio, Castro-Faria-Neto, Hugo Caire, Vieira, Rodolfo Paula
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Language:English
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Summary:[Display omitted] Some pro-inflammatory lipids derived from 1 lipooxygenase enzyme are potent neutrophil chemoattractant, a cell centrally involved in acute respiratory distress syndrome (ARDS); a syndrome lacking effective treatment. Considering the beneficial effects of the leukotriene receptor inhibitor, montelukast, on other lung diseases, whether montelukast attenuates inflammation in a mouse model of ARDS, and whether it reduces LPS stimulated activation of human neutrophils was investigated. Thirty-five C57Bl/6 mice were distributed into control (PBS)+24h, LPS+24h (10μg/mouse), control+48h, LPS+48h, and LPS 48h+Montelukast (10mg/kg). In addition, human neutrophils were incubated with LPS (1μg/mL) and treated with montelukast (10μM). Oral-tracheal administration of montelukast significantly attenuated total cells (P
ISSN:0300-2896
1579-2129
DOI:10.1016/j.arbres.2019.05.003