Methionine as a double-edged sword in health and disease: Current perspective and future challenges

Methionine is one of the essential amino acids and plays a vital role in various cellular processes. Reports advocate that methionine restriction and supplementation provide promising outcomes, and its regulation is critical for maintaining a healthy life. Dietary methionine restriction in houseflie...

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Published in:Ageing research reviews 2021-12, Vol.72, p.101500, Article 101500
Main Authors: Navik, Umashanker, Sheth, Vaibhav G., Khurana, Amit, Jawalekar, Snehal Sainath, Allawadhi, Prince, Gaddam, Ravinder Reddy, Bhatti, Jasvinder Singh, Tikoo, Kulbhushan
Format: Article
Language:English
Subjects:
Aging
AMPK
Body Weight
Diet
FGF-21
Humans
Insulin Resistance
Insulin sensitivity
Longevity
Methionine
Methionine restriction
Methionine supplementation
mTOR
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Summary:Methionine is one of the essential amino acids and plays a vital role in various cellular processes. Reports advocate that methionine restriction and supplementation provide promising outcomes, and its regulation is critical for maintaining a healthy life. Dietary methionine restriction in houseflies and rodents has been proven to extend lifespan. Contrary to these findings, long-term dietary restriction of methionine leads to adverse events such as bone-related disorders, stunted growth, and hyperhomocysteinemia. Conversely, dietary supplementation of methionine improves hepatic steatosis, insulin resistance, inflammation, fibrosis, and bone health. However, a high level of methionine intake shows adverse effects such as hyperhomocysteinemia, reduced body weight, and increased cholesterol levels. Therefore, dietary methionine in a safe dose could have medicinal values. Hence, this review is aimed to provide a snapshot of the dietary role and regulation of methionine in the modulation of health and age-related diseases. •Methionine is an essential amino acid and plays a crucial role in modulation of health.•Methionine restriction has both beneficial and detrimental effects.•Likewise, supplementation of methionine possesses both protective and destructive effects.•The usage of methionine as a dietary intervention in safer limits could have medicinal values and can modulates the aging process.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2021.101500