Prevalence of hypertriglyceridemia in adults and related cardiometabolic factors. SIMETAP-HTG study

• Published in: Clínica e investigación en arteriosclerosis (Internet, English ed.) English ed.), 2020-11, Vol.32 (6), p.242-255
• Main Authors: Ruiz-García, Antonio, Arranz-Martínez, Ezequiel, López-Uriarte, Beatriz, Rivera-Teijido, Montserrat, Palacios-Martínez, David, González-Posada Delgado, José Antonio, Mariño-Suárez, José Enrique, Íscar-Valenzuela, Ignacio, Alonso-Roca, Rafael, Isabel Gutiérrez Sánchez, M., Inmaculada Hernández-Beltrán, M., Fernández, Montserrat Pérez, Prieto Marcos, Miguel, Delgado Rodríguez, Santiago, Pleite Raposo, Raquel, Rosario Morales-Chico, M., Fernández-Pacheco Vila, Diana, Remón-Pérez, Beatriz, Redondo, M. Jesús del Villar, Reguillo-Díaz, Joaquina, Rodríguez, Ana Olga Rodríguez, Antón-Sanz, M. del Carmen, Sánchez-Calso, Antonio, Doria-Carlin, Norma Alejandra, Abad Schilling, C., Adrián Sanz, M., Aguilera Reija, P., Alcaraz Bethencourt, A., Arranz Martínez, E., Baltuille Aller, M.C., Barrios Rueda, E., Berbil Bautista, M.L., Blanco Canseco, J.M., Caballero Ramírez, N., Cabrera Vélez, R., Capitán Caldas, M., Casaseca Calvo, T.F., Cique Herráinz, J.A., Chao Escuer, P., Dávila Blázquez, G., de la Peña Antón, N., de Prado Prieto, L., del Villar Redondo, M.J., Delgado Rodríguez, S., Durán Tejada, M.R., Escrivá Ferrairó, R.A., Fernández-Pacheco Vila, D., Frías Vargas, M.J., García Álvarez, J.C., García Fernández, M.E., García Alcañiz, M.P., García Granado, M.D., García Pliego, R.A., García Redondo, M.R., García Villasur, M.P., Gómez Díaz, E., González Escobar, P., Gutiérrez Sánchez, I., Hernández Beltrán, M.I., Hernández López, R.M., Hidalgo Calleja, Y., Holgado Catalán, M.S., Hombrados Gonzalo, M.P., Hueso Quesada, R., Ibarra Sánchez, A.M., Íscar Valenzuela, I., Iturmendi Martínez, N., López Uriarte, B., Martín Fernández, A.I., Martínez Cid de Rivera, E., Martínez Irazusta, J., Migueláñez Valero, A., Montero Costa, A., Mora Casado, C., Moreno Fernández, J.C., Moreno Muñoz, M.S., Palacios Martínez, D., Pérez Muñoz, R., Prieto Marcos, M., Redondo de Pedro, S., Redondo Sánchez, M., Rey López, A.M., Ribot Catalá, C., Rico Pérez, M.R., Rivera Teijido, M., Rodríguez Cabanillas, R., Rodríguez de Cossío, A., Rodríguez de Mingo, E., Rodríguez, A.O., Rubio Villar, M., Ruiz Díaz, L., Sánchez Calso, A., Sánchez Herráiz, M., Sánchez Ramos, M.C., Sarriá Sánchez, M.T., Tello Meco, I., Velazco Zumarrán, J.L., Vieira Pascual, M.C., Zafra Urango, C., Zamora Gómez, M.M.
• Format: Article
• Language: English
• Subjects: Adult; Adulto; Hipertrigliceridemia; Hypertriglyceridaemia; Prevalence; Prevalencia
• ISSN: 2529-9123; 2529-9123
• DOI: 10.1016/j.artere.2020.11.002

To determine in the adult population the crude and the sex- and age-adjusted prevalence rates of hypertriglyceridaemia (HTG) and to assess its association with cardiovascular risk factors, chronic kidney disease, cardiovascular and cardiometabolic diseases. Cross-sectional observational study conducted in Primary Care, with 6,588 adult study subjects, randomly selected on base-population. Patients had HTG if the triglyceride level was ≥150 mg/dL (≥1.7 mmol/L), or were on lipid-lowering therapy to lower triglyceride. Associations were assessed by univariate and multivariate analysis, and crude and sex- and age-adjusted prevalence rates were determined. The arithmetic and geometric means of triglyceride levels were respectively 120.5 and 104.2 mg/dL in global population, 135.7 and 116.0 mg/dL in men, and 108.6 and 95.7 mg/dL in women. The crude HTG prevalence rates were 29.6% in global population, 36.9% in men and 23.8% in women. The sex- and age-adjusted HTG prevalence rates were 27.0% in global population, 34.6% in men and 21.4% in women. The independent variables that were most associated with HTG were hypercholesterolemia (OR: 4.6), low HDL-C (OR: 4.1), hepatic steatosis (OR: 2.8), diabetes (OR: 2.0), and obesity. (OR: 1.9). The means of triglyceride levels and HTG prevalence rates are intermediate between those of other national and international studies. A fifth of the female adult population and more than a third of the male population had HTG. The independent factors associated with HTG were hypercholesterolemia and low HDL-C, and the cardiometabolic variables diabetes, hepatic steatosis and obesity. Determinar en la población adulta las tasas de prevalencia crudas y ajustadas por edad y sexo de hipertrigliceridemia (HTG) y valorar su asociación con factores de riesgo cardiovascular, enfermedad renal crónica, enfermedades cardiovasculares y cardiometabólicas. Estudio observacional transversal realizado en Atención Primaria, con 6.588 sujetos de estudio adultos, seleccionados aleatoriamente con base poblacional. Los pacientes tenían HTG si la concentración de triglicéridos era ≥150 mg/dL (≥1,7 mmol/L), o estaban en tratamiento hipolipemiante para reducir los triglicéridos. Se valoraron las asociaciones mediante análisis univariado y multivariante, y se determinaron las prevalencias crudas y ajustadas por edad y sexo. Las medias aritméticas y geométricas de las concentraciones de triglicéridos fueron respectivamente 120,5 y 104,2 mg/dL en la población