Incorporation of biochemical parameters and diagnostic algorithms in the laboratory computer system for the early detection of lipid abnormalities from the lipid units

• Published in: Clínica e investigación en arteriosclerosis (Internet, English ed.) English ed.), 2021-11, Vol.33 (6), p.273-281
• Main Authors: Arrobas Velilla, Teresa, Bonet Estruch, Elena, Roa Garrido, Jessica, Romero Jiménez, Manuel, Varo Sánchez, Gema María, Vázquez Rico, Ignacio
• Format: Article
• Language: English
• Subjects: Algoritmos bioquímicos; Apolipoprotein B; Apolipoproteína B; Biochemicals algorithms; Cardiovascular risk; Dislipidemia; Dyslipidemia; Lipid units; Lipoprotein (a); Lipoproteína (a); Riesgo cardiovascular; Unidades de lípidos
• ISSN: 2529-9123; 2529-9123
• DOI: 10.1016/j.artere.2021.11.001

The combination of biochemical markers, together with the design and implementation of diagnostic algorithms in laboratory computer systems could become very powerful tools in the stratification of cardiovascular risk. To implement new biochemical markers and diagnostic algorithms not yet available, in order to provide an estimation of cardiovascular risk and the diagnostic orientation of lipid alterations. Study of the implementation of Apolipoprotein B and Lipoprotein (a), as well as the inclusion of different diagnostic algorithms. This was carried out jointly by the different Lipid Units of the Spanish Society of Atherosclerosis, Hospital Virgen Macarena in Seville, Hospital Juan Ramon Jiménez, Hospital Infanta Elena, and Hospital de Rio Tinto during 2018 and 2019. The four diagnostic algorithms entered into the Laboratory Information System (LIS), showed a total of 9985 patients with c-LDL >200 mg/dL. The diagnostic algorithm was extended to include Apo B, with 8182 determinations showing an Apolipoprotein B > 100 mg/dL). A total of 747 lipoprotein (a) were determined, of which 30.65% were >50 mg/dL. More than two-thirds (71.80%) showed results compatible with small and dense LDL particles. The implementation of new analytical parameters and algorithms in Primary Care laboratory results can identify a considerable number of patients with different alterations in lipid metabolism. This, together with the classic risk factors, could contribute to a correct risk stratification in preventing the progression of CVD. La combinación de marcadores bioquímicos así como el diseño e implementación de algoritmos diagnósticos en el sistema informático de los laboratorios podrían convertirse en herramientas muy potentes en la estratificación del riesgo cardiovascular. Implementación de nuevos marcadores bioquímicos y algoritmos diagnósticos hasta ahora no disponibles para facilitar la estimación del riesgo cardiovascular y la orientación diagnostica de las alteraciones lipídicas. Estudio para la implementación de Apolipoproteína B y la Lipoproteína (a) así como la inclusión de diferentes algoritmos diagnósticos. Se ha realizado conjuntamente entre las diferentes unidades de lípidos de la Sociedad Española de arteriosclerosis, Hospital Virgen Macarena de Sevilla, Hospital Juan Ramon Jiménez, Hospital Infanta Elena y Hospital de Rio tinto durante año 2018 y 2019. Se han aplicado 4 algoritmos diagnósticos en el SIL que mostraron 9.985 pacientes totales con c-LDL >200